NSAIDs in a Patient with Fractures?!

NSAIDs in a Patient with Fractures?!

The Issue

NSAIDs are excellent analgesics that can decrease the use of opiatess for pain, but might lead to poor healing from orthopedic injuries.

Prior Evidence

In vitro studies and rat models since the early 80s showed delayed fracture healing with NSAIDs, and the effects appeared to be dose-related. These findings have been re-demonstrated in future in vitro and rat studies as well.   In humans however, the data has been, to say the least, mixed...

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