Grand Rounds Recap 7.25.18

Grand Rounds Recap 7.25.18

This week started with our monthly Morbidity and Mortality conference where we discussed posterior MIs, tough dissections and more tough cases. We then heard a debate on the use of D-Dimer in the diagnosis of aortic dissection. Finally, we were led through a simulation of a sick GI bleed requiring Minnesota tube placement, and we discussed optimal management of these challenging patients.

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NSAIDs in a Patient with Fractures?!

NSAIDs in a Patient with Fractures?!

The Issue

NSAIDs are excellent analgesics that can decrease the use of opiatess for pain, but might lead to poor healing from orthopedic injuries.

Prior Evidence

In vitro studies and rat models since the early 80s showed delayed fracture healing with NSAIDs, and the effects appeared to be dose-related. These findings have been re-demonstrated in future in vitro and rat studies as well.   In humans however, the data has been, to say the least, mixed...

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