Ketamine Fight Club: Ketamine in TBI

Ketamine Fight Club: Ketamine in TBI

There has long been a concern for increases in ICP with administration of ketamine primarily stemming from reports of increased ICP in the Neurosurgery and Neuroanesthesia literature.  These increases were described primarily in patients usually with CSF outflow obstruction undergoing elective neurosurgical procedures.  In the time since these articles were published, the use of ketamine in a wide variety of patients with neurologic compromise has been reported.  In fact, there have been a couple of recent systematic reviews and meta-analyses on this topic.  These systematic reviews and meta-analyses have essentially analyzing all the same existing literature (which is generally poor in quality).  

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